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KMID : 0363219770150040483
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Korean Journal of Dermatology
1977 Volume.15 No. 4 p.483 ~ p.492
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Scleroderma Treated with Penicillamine-D
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Abstract
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Scleroderma is an incidious and chronic disease of unknown cause. The clinical picture of scleroderma is characterized by the appearance of circumscribed of diffuse, hard, smooth,ivory colored areas that are immobile upon the underlying tissues.
It may be classified to as a localized form (morphea) and a systemic scleroderma or progressive systemic sclerosis (PSS) which is characterized by diffuse involvement of the connective tissue of the skin and certain internal organs.
The authors observed 3 cases of PSS and 6 cases of morphea. They have complained of marked sclerosis or thickening of skin or slowly developing dyspnea due to interstitial pulmonary fibrosis which were confirmed by chest X-ray.
Recently, penicillamine-D has been advocated as a beneficial agent in scleroderma by Asboe-Hansen.
Therefore, penicillamine-D was administered to the above patients.
Two of PSS were markedly improved with normal skin softness.
Two of morphea were also moderately improved.
Other-patients remained stationary or no effect.
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